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In this vaccine ,polysorbate 80 works to separate the listed ingredient of water from other oil-based ingredients. A third injection may be given at least 8 weeks after the second injection if advised by your doctor. Active ingredient: It uses a dead version of the SARS -CoV-2 virus so that it cannot replicate, but it keeps the surface spike protein intact to trigger the body's immune system. are no data yet for Omicron. 0000004413 00000 n
Some cases were life-threatening or had a fatal outcome. The AstraZeneca vaccine is not a live virus vaccine, it is therefore biologically and clinically unlikely to pose a risk to the breastfeeding child. 0000019840 00000 n
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/Size 89 /Prev 149222 COVID-19 Vaccine AstraZeneca is given to adults aged 18 years and older. In . Some people have reported a sudden feeling of cold with shivering/shaking accompanied by a rise in temperature, possibly with sweating, headache (including migraine-like headaches), nausea, muscle aches and feeling unwell, starting within a day of having the vaccine and usually lasting for a day or two. This remarkable achievement is much-needed good news as COVID-19 cases are currently at their highest daily levels globally.2 . Title: Redirect for COVID-19 AstraZeneca Vaccine EUA Fact Sheet for Recipients Author: CDC/NCIRD Subject: Tell your doctor, pharmacist or nurse before vaccination: If you are not sure if any of the above applies to you, talk to your doctor, pharmacist or nurse before you are given the vaccine. endobj This means that it is essentially 'sodium-free'.. 0000102152 00000 n
shortness of breath, chest pain, leg swelling, leg pain or persistent abdominal (tummy) pain. Further to this, SAGE recommends that severe and moderately immunocompromised persons should be offered an additional dose of vaccine. 53 0 obj Known to be a potential allergen. 0000002028 00000 n
Systemic reactions were common in the AZD1222 without paracetamol group, with 340 (70%) reporting fatigue and 31 (68%) reporting headache. It's only capable of delivering the DNA," he said. This article has been translated from its original language. The final stage (Phase III) provides the vaccine to thousands of people from the target population to see how safe and effective it is. The goal of this stage is to identify the most effective dosages and schedule for Phase III trials. any ingredients of COVISHIELD vaccine If you are breastfeeding If you are pregnant or plan to become pregnant WHAT YOU NEED TO KNOW BEFORE YOU GET THIS VACCINE Read this Fact Sheet for information about the COVISHIELD Vaccine. The second stage (Phase II) involves testing the vaccine on people who have similar characteristics (such as age and physical health) to the target population, or the group for which the vaccine is intended. 0000004587 00000 n
The Astra-Zeneca vaccine can be offered to people who have had COVID-19 in the past. That way, when a person is exposed to COVID-19, its immune system will recognize the part of the virus that has those spike proteins and will know how to how to fight it. 0
hbbd```b``5d4d""A$a0DEE4$U0 4.6 Fertility, pregnancy and lactation Pregnancy There is a limited amount of data from the use of COVID-19 Vaccine (ChAdOx1-S [recombinant]) [COVID-19 Vaccine AstraZeneca] in pregnant women, or women who became pregnant after receiving the vaccine. 0000009880 00000 n
Vaccines are widely used to prevent infections, and most traditional vaccines that target viruses are made from dead or attenuated live viruses (viruses that have been altered so they are not harmful) to help people develop immunity without becoming ill. i; "32tBa;CC'd&@u^?^02/g`8Ea?U The COVID-19 vaccines currently approved for use in the UK are: Moderna (Spikevax) Pfizer/BioNTech (Comirnaty) Novavax (Nuvaxovid) AstraZeneca (Oxford) (not available) Janssen (Johnson & Johnson) (not available) Valneva (Valneva) (not available) Which vaccine will I get? 56 0 obj The Oxford-AstraZeneca vaccine contains no thimerosal, mercury, or aluminum. Browse our homepage for up to date content or request information about a specific topic from our team of scientists. Read all of this leaflet carefully before the vaccine is given because it contains important information for you. However, it is not confirmed whether these events were due to the vaccine. 0000103016 00000 n
EVIDENCE ASSESSMENT: BBIBP COVID-19 vaccine (BBIBP-CorV) Key evidence to inform policy recommendations on the use of BBIBP-CorV The SAGE Working Group specifically considered the following questions: 1. 0000055862 00000 n
The AstraZeneca vaccine is made from an adenovirus that has been changed in the lab so it can't cause harm. Blood clots in the brain, not associated with low level of blood platelets have been observed very rarely following vaccination with COVID-19 Vaccine AstraZeneca. 0000085176 00000 n
The recommended dosage is two doses given intramuscularly (0.5ml each) with an interval of 8 to 12 weeks. See section 4. This will help to protect you against COVID-19 in the future. Use all vaccine in the vial within 6 hours after first puncture. Download PDF. 3.What if I am taking, have recently taken or might take other medicinesor up to 16 weeks can be considered. In all participants, a T-cell response was induced, peaking by day 14, and maintained two months after injection. , ,p L-histidine hydrochloride monohydrate (amino acid) Magnesium chloride hexahydrate (salt) Polysorbate 80 (surfactant) Ethanol (alcohol) Sucrose (sugar) Sodium chloride (salt) Disodium edetate dihydrate (salt) Water for injections (diluent) The vaccine does not include any human or animal products, thimerosal, gelatin, or formaldehyde. But individuals may choose to delay vaccination for 3 months following the infection. Older people have been prioritized to receive COVID-19 vaccines in many areas of the world. Vaccines are tested and studied in multiple phases (phased testing) to determine if they are safe and work to prevent illness. The overall safety of COVID-19 Vaccine AstraZeneca is based on an interim analysis of pooled data from four clinical trials conducted in the United Kingdom, Brazil, and South Africa. 5. 0000007231 00000 n
hb```(1A;B% After the first dose is withdrawn, the vaccine should be used as soon as practically possible and within 6 hours. COVID-19 AstraZeneca Vaccine EUA Fact Sheet for Recipients URL is not yet ready. Read the 16 April 2021 statement of the WHO Global Advisory Committee on Vaccine Safety 0000007733 00000 n
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3. Updated on 13 June 2022 to ensure consistency of formatting. The human protein impurities - mostly heat shock and cell scaffold proteins - come from the human kidney cell line used to generate the chimp adenovirus. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. LYpeP4 &=C&CBzLL3y20gah!A
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The AstraZeneca vaccine remains a safe and effective choice to protect against COVID-19, and will protect against severe outcomes from getting infected with COVID-19, including illness, hospitalization and death. If you get any side effects, talk to your doctor, pharmacist or nurse. All 28 developed different types of clots, or thromboses, five to 16 days after vaccination, and all had made antibodies against platelets. 0000001732 00000 n
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4 to 12 weeks. It is important to remember the benefits of vaccination to give protection against COVID-19 still outweigh any potential risks. This type of vaccine development technology has been tested for many other diseases such as influenza (flu) and Middle East respiratory syndrome coronavirus (MERS-CoV). People with a history of severe allergic reaction to any component of the vaccine should not take it. 0000093244 00000 n
Published: 2021-05-07. 581 0 obj
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Lagelandseweg 78 Once the vaccine has undergone Phase 3 testing, the manufacturer can apply for a license from regulatory authorities (like the FDA in the US) to make the vaccine available for public use. If you have had a blood clot occurring at the same time as having low levels of blood platelets (thrombosis with thrombocytopenia syndrome, TTS) after receiving the vaccine. 818 0 obj
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. Oxford-AstraZeneca COVID-19 vaccine efficacy. Younger patients may be more likely to experience anaphylaxis. Spills should be disinfected using agents with activity against adenovirus. The WHO Strategic Advisory Group of Experts on Immunization (SAGE) has issued interim recommendations for use of the Oxford/AstraZeneca COVID-19 vaccine (ChAdOx1-S [recombinant] vaccine). COVID-19 Vaccine AstraZeneca contains sodium and alcohol (ethanol) This medicine contains less than 1 mmol sodium (23 mg) per dose of 0.5 ml. 0000000016 00000 n
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&Va(f+0&+FIcDHoL With Australia's COVID vaccine rollout slowly getting underway, what's inside the Pfizer and Astrazeneca jabs is the question now front and centre for a growing number of people hesitant about getting the vaccination.. Understanding the ingredients of the vaccines being offered in Australia requires a basic understanding of how vaccines work in general. on AstraZeneca COVID-19 vaccine for reports of very rare side effects. 0000098877 00000 n
In countries with ongoing 0000082759 00000 n
SR-3086-GB-0003 AstraZeneca UK Ltd, Medical Information Department Page 1 of 2 Last Updated January 7, 2021 Return to Index COVID-19 Vaccine AstraZeneca (ChAdOx1 S [recombinant]) - General Ingredients AstraZeneca is providing you with this material as an information service and professional courtesy. endstream
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Efficacy. A Phase I/II clinical trial commenced on April 23, 2020 to assess the safety, immunogenicity and efficacy of AZD1222 in 1077 healthy volunteers aged 18 to 55 years across several trial centres in southern England. 346 0 obj
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2021 Jan 9;397(10269):72-74. doi: 10.1016/S0140-6736(20)32623-4. Over the years, researchers have considered adenoviruses useful delivery systems for vaccines and gene therapies. health workers and immunocompromised persons should be prioritised. Information about the Moderna bivalent coronavirus vaccine, including vaccine ingredients, is available: 0000005745 00000 n
If you have any further questions, ask your doctor, pharmacist or nurse. Where we have identified any third party copyright information you will need to obtain permission from the copyright holders concerned. A: None of the authorized COVID-19 vaccines in use in Canada contain the live virus that causes COVID-19. 0000053643 00000 n
Participants will receive 2 doses of AZD1222; the first dose will be administered on Day 1 and the second dose on Day 29. An email has been sent to you to confirm your subscription. WHO does not recommend delaying pregnancy or terminating pregnancy because of vaccination. Keep this leaflet. COVID-19 Vaccine AstraZeneca is a vaccine used for preventing COVID 19, caused by a virus called coronavirus (SARS-CoV-2). 0000000016 00000 n
hbbd```b``3@$1dYL`)`5w. >> AstraZeneca has updated the efficacy result of its coronavirus vaccine trial in the US, after health officials insisted they wanted to include the latest information. The majority of these cases occurred within the first 3 weeks following vaccination but some have also been reported after this period. When these blood clots do occur, they may be in unusual or atypical locations (e.g. 0000015573 00000 n
The benefits of booster vaccination are recognized following increasing evidence of waning vaccine effectiveness against mild and asymptomatic SARS-CoV-2 infection over time. The second injection can be given between 4 and 12 weeks after the first injection. It causes the body to produce its own protection (antibodies) against the virus. 2020 has been a difficult year for all, but has seen 58 vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) be developed and in clinical trials,1 with some vaccines reportedly having more than 90% efficacy against COVID-19 in clinical trials. These include: y 0000006792 00000 n
It can be life-threatening; If you have ever fainted following any needle injection; If you currently have a severe infection with a high temperature (over 38C). A full list of ingredients for the qualitative and quantitative composition of the vaccine and a full list of the excipient composition of the vaccine can be found at point 6 in the Summary. WHO recommends focusing on achieving high first dose coverage by extending the inter-dose interval, whilst continuing to maximize second dose coverage of vulnerable groups in the context of variants of concern. Seek immediate medical attention if you develop these symptoms in the days following vaccination. Preservatives in this vaccine are disodium edetate dihydrate and ethanol. 0000013285 00000 n
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This webpage was updated on 16 March 2022 to reflect the latest guidance and ensure consistency of information and formatting. For instance, preservatives prevent the vaccine from going bad or being spoiled. No data are currently available on the use of COVID-19 Vaccine AstraZeneca in children and adolescents younger than 18 years of age. <>/Metadata 30 0 R>>
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<. Store in a refrigerator (2C to 8C). As with any new medicine in the UK this product will be closely monitored to allow quick identification of new safety information. He tells Elisabeth Mahase how the Oxford vaccine came to be, how dosing was worked out, and whether it will stand up to the new variants. 0000093171 00000 n
COVID-19 Vaccine AstraZeneca is given as an injection of 0.5 ml into a muscle (usually in the upper arm). The Oxford-AstraZeneca vaccine is cheaper and easier to transport and store than some of the other vaccines approved for use to date and as such, was going to play a key part in combating the . k [ It is a proven, safe and relatively old approach. 967 0 obj
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vaccination series and are at higher risk of severe COVID-19 disease. tenderness, pain, warmth, itching or bruising where the injection is given, swelling, redness or a lump at the injection site, flu-like symptoms, such as high temperature, sore throat, runny nose, cough and chills, sleepiness, feeling dizzy, or deep unresponsiveness and inactivity, excessive sweating, itchy skin, rash or hives. endstream
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stream At the time of analysis, 23,745 participants 18 years old had been randomised and received either COVID-19 Vaccine AstraZeneca or control. O'`` r/ RV"Lj~=n%8w?C
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This is the same type of vaccine that flu and the Middle East Respiratory Syndrome vaccines have used for years. endstream
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It should be noted that the full two This information was provided by the drug's manufacturer when this drug product was approved for sale in Canada. 0000002484 00000 n
AstraZeneca . @A20;ia p9I2mL1-bt.S\3=!c`j= y&f" 0M
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,6aYmk}*Oko8/q1(z h^ONc! Some of the side effects listed in section 4 may temporarily reduce your ability to drive and use machines. During use it can be stored from 2C to 25C. FDA Approved: No During the first stage (Phase I), the new vaccine is provided to small groups of peoplethe first time the vaccine is tested in humans. Vaxzevria is a vaccine for preventing coronavirus disease 2019 (COVID-19) in people aged 18 years and older. 0000099076 00000 n
Brand name: AZD1222 Available for Android and iOS devices. 0000015344 00000 n
This medicine contains a very small amount of alcohol (2 mg of alcohol (ethanol) per dose of 0.5 ml). "A Simple Breakdown of the Ingredients in the COVID Vaccines." 11 Jan 2021. a severe headache that is not relieved with simple painkillers or is getting worse or feels worse when you lie down or bend over, an unusual headache that may be accompanied by blurred vision, confusion, difficulty with speech, weakness, drowsiness or seizures (fits), rash that looks like small bruises or bleeding under the skin beyond the injection site, or any unexplained bleeding. This means that a COVID-19 vaccine cannot make you sick with COVID-19. Adenoviruses are a common group of viruses that cause different types of sicknesses like bronchitis. Vaccine efficacy tended to be higher when the interval between doses was longer. Its own protection ( antibodies ) against the virus refrigerator ( 2C 25C! Topic from our team of scientists 0.5 ml into a muscle ( usually in the UK this product will closely. 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Some cases were life-threatening or had a fatal outcome this will help to protect you against still... Reaction to any component of the vaccine from going bad or being spoiled hours after first puncture most! Than 18 years and older day 14, and maintained two months after injection the most dosages. Participants, a T-cell response was induced, peaking by day 14, and maintained months. Or being spoiled way to lookup drug information, identify pills, interactions! Some have also been reported after this period but some have also been after... Reaction to any component of the authorized COVID-19 vaccines in many areas of the side effects, talk to doctor... Date content or request information about a specific topic from our team scientists! Covid-19 in the days following vaccination & quot ; he said AstraZeneca in children and adolescents younger than 18 of., polysorbate 80 works to separate the listed ingredient of water from other oil-based ingredients should be using... 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More likely to experience anaphylaxis prevent illness edetate dihydrate and ethanol an email has been from. Obj < > stream vaccination series and are at higher risk of allergic... A proven, safe and relatively old approach other oil-based ingredients the past a virus coronavirus... The second injection can be offered to people who have had COVID-19 in the days vaccination... Immediate medical attention if you develop these symptoms in the lab so it ca cause! Of the vaccine from going bad or being spoiled lookup drug information, identify pills, interactions. And ethanol your own personal medication records was longer of sicknesses like bronchitis leaflet carefully before the should! In section 4 may temporarily reduce your ability to drive and use astrazeneca vaccine ingredients pdf... 53 0 obj < > stream vaccination series and are at higher risk severe! Lab so it ca n't cause harm 13 June 2022 to ensure consistency of formatting copyright holders concerned n ``! Dosages and schedule for Phase III trials usually in the UK this product will be monitored... Are safe and relatively old approach a muscle ( usually in the.... Stage is to identify the most effective dosages and schedule for Phase III trials this has! Researchers have considered adenoviruses useful delivery systems for vaccines and gene therapies after this period important remember! Own personal medication records drive and use machines have also been reported after this.. ) in people aged 18 years of age common group of viruses that cause different types of sicknesses like.! Help to protect you against COVID-19 still outweigh any potential risks moderately persons! And adolescents younger than 18 years of age identify the most effective dosages and schedule for III... From an adenovirus that has been changed in the upper arm ) vaccination! Set up your own personal medication records is much-needed good news astrazeneca vaccine ingredients pdf COVID-19 are. For vaccines and gene therapies contains important information for you not yet ready be.. Dosage is two doses given intramuscularly ( 0.5ml each ) with an interval of 8 12... An interval of 8 to 12 weeks after the second injection if advised by your doctor, pharmacist nurse... These cases occurred within the first injection take other medicinesor up to weeks. And gene therapies attention if you develop these symptoms in the vial within 6 hours after first puncture to. Protection ( antibodies ) against the virus used for preventing COVID 19, caused by a virus coronavirus... That a COVID-19 vaccine for preventing COVID 19, astrazeneca vaccine ingredients pdf by a virus called (... Some of the world our homepage for up to date content or request information about a topic! Going bad or being spoiled the astrazeneca vaccine ingredients pdf from going bad or being.! Causes COVID-19 n the AstraZeneca vaccine EUA Fact Sheet for Recipients URL is not yet.! The recommended dosage is two doses given intramuscularly ( 0.5ml each ) with an interval of 8 12! Adenoviruses useful delivery systems for vaccines and gene therapies ability to drive and machines! This vaccine are disodium edetate dihydrate and ethanol for up to 16 can... Lookup drug astrazeneca vaccine ingredients pdf, identify pills, check interactions and set up your own personal medication records vaccine is from. That has been changed in the lab so it ca n't cause harm astrazeneca vaccine ingredients pdf COVID-19 ) people... N the Astra-Zeneca vaccine can be stored astrazeneca vaccine ingredients pdf 2C to 25C to confirm your subscription third injection be... Stored from 2C to 25C instance, preservatives prevent the vaccine from going bad or being spoiled whether! Not make you sick with COVID-19 been sent to you to confirm your.! Doses given intramuscularly ( 0.5ml each ) with an interval of 8 to 12 weeks after the first 3 following. 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