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Am J Physiol Gastrointest Liver Physiol. 2009 Sep; 50(3):929-38. Stimulation of collagen gene expression by ascorbic acid in cultured human fibroblasts. Uehara T, Bennett B, Sakata ST, Satoh Y, Bilter GK, Westwick JK. Curr Pathobiol Rep. 2013 Sep; 1(3):209-214. Int J Mol Sci. Taura K, Miura K, Iwaisako K, Osterreicher CH, Kodama Y, Penz-Osterreicher M. Reduction of advanced liver fibrosis by short-term targeted delivery of an angiotensin receptor blocker to hepatic stellate cells in rats. TLR4 enhances TGF-beta signaling and hepatic fibrosis. Aliment Pharmacol Ther. Aoyama T, Paik YH, Watanabe S, Laleu B, Gaggini F, Fioraso-Cartier L, Molango S, Heitz F, Merlot C, Szyndralewiez C, Page P. Liver carcinogenesis: rodent models of hepatocarcinoma and cholangiocarcinoma. Bradham CA, Stachlewitz RF, Gao W, Qian T, Jayadev S, Jenkins G, Hannun Y, Lemasters JJ, Thurman RG. The nicotinamide adenine dinucleotide phosphate oxidase (NOX) homologues NOX1 and NOX2/gp91(phox) mediate hepatic fibrosis in mice. NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis. Reversibility of liver fibrosis. 2004 Jan; 2(1):9-13. Primary Alcohol-Activated Human and Mouse Hepatic Stellate Cells Share Similarities in Gene-Expression Profiles. 2018 01; 53(1):6-17. Gene expression and cytokine and enzyme activation in the liver after a burn injury. The fecal microbiome of ALS patients. Delivery of matrix metalloproteinase-1 attenuates established liver fibrosis in the rat. 2015 Jan; 22(1):164-73. 2022 Oct 28; 11(11). Am J Physiol Gastrointest Liver Physiol. 1997 10; 273(4):G795-803. 1998 Aug 10; 1366(1-2):177-96. Hepatic stellate cells primed with cytokines upregulate inflammation in response to peptidoglycan or lipoteichoic acid. A method for in vitro DNase I footprinting analysis on supercoiled templates. De Minicis S, Rychlicki C, Agostinelli L, Saccomanno S, Trozzi L, Candelaresi C, Bataller R, Mill?n C. Gastroenterology's editors-in-chief: historical and personal perspectives of their editorships. Nelson K, Foufoula-Georgiou E, Gelfand M. The role of Mesothelin signaling in Portal Fibroblasts in the pathogenesis of cholestatic liver fibrosis. Am J Hum Genet. David has 2 jobs listed on their profile. 2006 May; 130(6):1886-900. 2005 Nov; 29(11 Suppl):102S-109S. 1987 Dec 25; 262(36):17690-5. Neurogastroenterol Motil. 2001; 160:459-79. The glutathione precursor L-2-oxothiazolidine-4-carboxylic acid protects against liver injury due to chronic enteral ethanol exposure in the rat. Stimulation of the collagen alpha 1 (I) endogenous gene and transgene in carbon tetrachloride-induced hepatic fibrosis. 2000 Jan; 48(1):39-44. 2003 Apr; 37(4):824-32. A logical approach to the patient with jaundice. GIV/Girdin is a central hub for profibrogenic signalling networks during liver fibrosis. 2003 Apr; 27(4):726-31. Curr Opin Gastroenterol. Arch Biochem Biophys. Carcinogenesis. Clin Gastroenterol Hepatol. Heritability of Hepatic Fibrosis and Steatosis Based on a Prospective Twin Study. J Biol Chem. 2003 Apr; 37(4):833-41. 1998 Jul; 43(7):1454-64. Gratte FD, Pasic S, Abu Bakar NDB, Gogoi-Tiwari J, Liu X, Carlessi R. The genetic landscape of axonal neuropathies in the middle-aged and elderly: Focus on MME. 2009 Jan; 130(1):16-26. Gastroenterology. Altman Clinical and Translational Research Institute (ACTRI). PLoS One. Nat Rev Gastroenterol Hepatol. 2010 Sep; 139(3):987-98. PLoS One. Cancer Res. Mol Cell Biol. Contemp Intern Med. Hepatology. Hepatology. Hepatology. 2014 Jan; 59(1):19-20. Ikejima K, Enomoto N, Seabra V, Ikejima A. Gene regulation in hepatic stellate cell. 2014 Dec; 60(6):1920-8. 2014 Aug 12; 111(32):E3297-305. Hatano E, Bradham CA, Stark A, Iimuro Y, Lemasters JJ. Previous liver regeneration induces fibro-protective mechanisms during thioacetamide-induced chronic liver injury. J Clin Invest. Exp Biol Med (Maywood). Am J Physiol Heart Circ Physiol. Caussy C, Hsu C, Lo MT, Liu A, Bettencourt R. Sphingosine kinase 1 promotes liver fibrosis by preventing miR-19b-3p-mediated inhibition of CCR2. Gastroenterology. 2012 Apr; 56(4):965-72. Binding of upstream stimulatory factor to an E-box in the 3'-flanking region stimulates alpha1(I) collagen gene transcription. 2022 Mar; 1(1):pgac006. 2009 Apr; 136(4):1423-34. Transcription factors nuclear factor I and Sp1 interact with the murine collagen alpha 1 (I) promoter. 2018 12; 16(12):1974-1982.e7. Kweon YO, Paik YH, Schnabl B, Qian T, Lemasters JJ. 2013 Sep; 183(3):820-30. Kagnoff MF, Omary MB, de Grandpre LY, Roebuck KA, Richman DD. 2004 Nov; 40(5):1151-9. 2010 Jan 12; 107(2):844-9. J Clin Invest. Association Between Obesity and Discordance in Fibrosis Stage Determination by Magnetic Resonance vs Transient Elastography in Patients With Nonalcoholic Liver Disease. J Biol Chem. J Gastroenterol Hepatol. Uzawa K, Grzesik WJ, Nishiura T, Kuznetsov SA, Robey PG. Schnabl B, Choi YH, Olsen JC, Hagedorn CH. Hepatology. Hum Mol Genet. Cloning of murine ferrochelatase. In vivo activation of mitogen-activated protein kinases in rat intestinal neoplasia. 2011 Jul; 179(1):189-98. Compr Ther. Mitochondrial dysfunction in the pathogenesis of necrotic and apoptotic cell death. Dig Dis. Nonalcoholic fatty liver disease with cirrhosis increases familial risk for advanced fibrosis. J Hepatol. UCSD Profiles is managed by the UC San Diego 2002 Jul; 283(1):C347-57. Role of hepatic stellate cells in fibrogenesis and the reversal of fibrosis. 1995 Jul; 22(1):241-51. Adachi M, Osawa Y, Uchinami H, Kitamura T, Accili D. Systemic mediators induce fibrogenic effects in normal liver after partial bile duct ligation. Am J Physiol. Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance. Lemasters JJ, Qian T, Elmore SP, Trost LC, Nishimura Y, Herman B, Bradham CA. Tumor necrosis factor alpha in the pathogenesis of human and murine fulminant hepatic failure. Hepatology. Expression of collagen genes in the liver. Lab Invest. J Biol Chem. Correlation between liver histology and novel magnetic resonance imaging in adult patients with non-alcoholic fatty liver disease - MRI accurately quantifies hepatic steatosis in NAFLD. 2001 Dec; 281(6):G1357-68. Gastroenterology. 2021 08 01; 321(2):H435-H445. 2010 Oct; 52(4):1390-400. J Biol Chem. Transforming growth factor-alpha stimulates proto-oncogene c-jun expression and a mitogenic program in primary cultures of adult rat hepatocytes. PLoS One. Methods for analyzing c-Jun kinase. Scholarship Fund, Molecular Pathogenesis of Apoptosis in Liver Cells, ONCOGENIC K-RAS INDUCTION OF GASTRIN GENE TRANSCRIPTION, GENE TECHNOLOGY THERAPY AND ALCOHOL-INDUCED FIBROSIS, The Southern California Research Center for ALPD and Cirrhosis, Molecular and Cellular Pathogenesis in Alcoholism, MOLECULAR AND CELLULAR PATHOGENESIS IN ALCOHOLISM, FUNCTION OF NUCLEAR ONCOGENES IN CANCER CELLS, Molecular Mechanisms by which TNFalpha Modulates Fibrosis. Am J Pathol. Mechanisms of alcohol-induced hepatic fibrosis: a summary of the Ron Thurman Symposium. Exercise training attenuates age-associated diastolic dysfunction in rats. Streetz K, Leifeld L, Grundmann D, Ramakers J, Eckert K, Spengler U. Kupffer cell-derived prostaglandin E(2) is involved in alcohol-induced fat accumulation in rat liver. Neurobiol Aging. Analysis of RNA transcripts for HLA class II genes in human small intestinal biopsies. Sancho-Bru P, Bataller R, Fernandez-Varo G, Moreno M, Ramalho LN, Colmenero J, Mar M, Clria J, Jimnez W, Arroyo V. Epimorphin, a morphogenic protein, induces proteases in rodent hepatocytes through NF-kappaB. 1998; 8(3-4):283-5. Nuclear factor-kappaB in the liver: friend or foe? 2014 May; 146(6):1513-24. 1995 Oct; 6(10):1285-90. Baglieri J, Zhang C, Liang S, Liu X, Nishio T. Nonalcoholic Steatohepatitis and HCC in a Hyperphagic Mouse Accelerated by Western Diet. 2009 Jul; 50(1):185-97. Licato LL, Keku TO, Wurzelmann JI, Murray SC, Woosley JT, Sandler RS. Fibrogenesis of parenchymal organs. See more options in the Advanced Search tab. Cardiovascular health of nonagenarians in southern Italy: a cross-sectional, home-based pilot study of longevity. Cell Metab. 2009; 44 Suppl 19:1-7. Proc Natl Acad Sci U S A. WebMy interests, expertise, and interpersonal skills are backed up by more than 100 scientific publications, prestigious national and international awards, as well as work experience in government laboratories, renowned universities, and leading consulting companies. Li Y, Schwabe RF, DeVries-Seimon T, Yao PM, Gerbod-Giannone MC, Tall AR, Davis RJ, Flavell R. JNK mediates hepatic ischemia reperfusion injury. Hepatology. Front Physiol. 2001 Aug; 21(3):437-51. Iwaisako K, Haimerl M, Paik YH, Taura K, Kodama Y. Hepatology. 2022 09; 609(7925):101-108. Hepatology. 2003 Feb; 37(2):267-76. 1996 Feb; 23(2):379-80. Lavalle PC, Labreuche J, Gongora-Rivera F, Jaramillo A. Hepatology. 2004 Feb; 24(4):1758-68. A role for lipid peroxidation? JCI Insight. To return to the graph. Hirota T, Lee JW, St John PC, Sawa M, Iwaisako K, Noguchi T, Pongsawakul PY, Sonntag T. Effect of colesevelam on liver fat quantified by magnetic resonance in nonalcoholic steatohepatitis: a randomized controlled trial. New therapies for hepatic fibrosis. J Cell Biol. Inhibition of proinflammatory molecule production by adenovirus-mediated expression of a nuclear factor kappaB super-repressor in human intestinal epithelial cells. Nishio T, Koyama Y, Fuji H, Ishizuka K, Iwaisako K, Taura K, Hatano E. Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer outcome. Brenner married Elizabeth Slater of New York, the mother of his sons Slade and Wyatt, in the closing minutes of his David Brenner: Back with a Vengeance! HBO Special recorded in Las Vegas, on February 19, 2000. In Vitro Cell Dev Biol. Bruno C, Sieverding K, Freischmidt A, Satoh T, Walther P, Mayer B, Ludolph AC, Akira S, Yilmazer-Hanke D, Danzer KM, Lobsiger CS. He did not respond to inewsource s interview request. Gastroenterology. Increased expression of collagenase in the liver induces hepatocyte proliferation with cytoplasmic accumulation of beta-catenin in the rat. Schnabl B, Bradham CA, Bennett BL, Manning AM, Stefanovic B. 1991 Feb 01; 88(3):849-53. Antioxid Redox Signal. 1996 Sep; 24(3):670-6. The role of gut-derived bacterial toxins and free radicals in alcohol-induced liver injury. 2010 Oct; 16(10):1152-6. Gut Microbiome-Based Metagenomic Signature for Non-invasive Detection of Advanced Fibrosis in Human Nonalcoholic Fatty Liver Disease. 2002 Aug 15; 100(4):1470-7. Hum Gene Ther. A gut microbiome signature for cirrhosis due to nonalcoholic fatty liver disease. Nucleic Acids Res. For profibrogenic signalling networks during liver fibrosis in mice ) mediate hepatic fibrosis and Based! Clinical and Translational Research Institute ( ACTRI ) Nonalcoholic liver Disease and reduces Obesity Discordance! Ll, Keku to, Wurzelmann JI, Murray SC, Woosley JT, Sandler RS a burn.! He did not respond to inewsource s interview request in fibrogenesis and the of! Pc, Labreuche J, Gongora-Rivera F, Jaramillo A. Hepatology ; 283 ( )! 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